The donation interval of 56 days requires extension to 180 days for whole blood donors to recover from changes in iron metabolism

Abstract

AMR-mediated hepatic platelet clearance in vivo may represent a physiological mechanism involved in platelet homeostasis.Platelets desialylate as they circulate, thereby becoming the primary ligand for the AMR, 10 and this interaction regulates hepatocyte thrombopoietin production.11 Desialylation also occurs when platelets are activated by several physiological stimuli, and AMR clearance may be relevant in attenuating the coagulopathy of sepsis.[12][13][14] Our results support the indications of international ITP guidelines, 15 which suggest that both PSSs and glycoprotein-specific antibody testing are not mandatory in ITP workup or management.However, if available on a single-center basis, these tests may help to gain insight into the prevalent mechanism underlying thrombocytopenia (increased clearance vs deficient production) in a specific patient who fails first-line therapy with glucocorticoids.

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