Articlebronze2016

Sleep disturbances and cognitive decline in the Northern Manhattan Study

Alberto R. Ramos · Hannah E. Gardener · Tatjana Rundek · Mitchell S.V. Elkind · Bernadette M Boden-Albala · Chuanhui Dong +4 more

31 citations0/0 files storedNeurology

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Abstract

OBJECTIVE: To examine frequent snoring, sleepiness, and sleep duration with baseline and longitudinal performance on neuropsychological (NP) battery. METHODS: The analysis consists of 711 participants of the Northern Manhattan Study (NOMAS) with sleep data and NP assessment (age 63 ± 8 years, 62% women, 18% white, 17% black, 67% Hispanic) and 687 with repeat NP testing (at a mean of 6 ± 2 years). The main exposures were snoring, sleepiness, and sleep duration obtained during annual follow-up. Using factor analysis-derived domain-specific Z scores for episodic memory, language, executive function, and processing speed, we constructed multivariable regression models to evaluate sleep symptoms with baseline NP performance and change in performance in each NP domain. RESULTS: In the cross-sectional analysis, adjusting for demographics and the NOMAS vascular risk score, participants with frequent snoring had worse executive function (β = -12; p = 0.04) and processing speed (β = -13; p = 0.02), but no difference in with episodic memory or language. Those with severe daytime sleepiness (β = -26; p = 0.009) had worse executive function, but no changes in the other NP domains. There was no cross-sectional association between sleep duration and NP performance. Frequent snoring (β = -29; p = 0.0007), severe daytime sleepiness (β = -29; p = 0.05), and long sleep duration (β = -29; p = 0.04) predicted decline in executive function, adjusting for demographic characteristics and NOMAS vascular risk score. Sleep symptoms did not explain change in episodic memory, language, or processing speed. CONCLUSIONS: In this race-ethnically diverse community-based cohort, sleep symptoms led to worse cognitive performance and predicted decline in executive function.

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References

2014Connections between sleep and cognition in older adults 2010Sleep duration and cardiometabolic risk: A review of the epidemiologic evidence 2012Evidence-Based Indicators of Neuropsychological Change in the Individual Patient: Relevant Concepts and Methods 1998Correlates of Daytime Sleepiness in 4578 Elderly Persons: The Cardiovascular Health Study 2012Excessive Sleepiness is Predictive of Cognitive Decline in the Elderly 2004Sleep and Reported Daytime Sleepiness in Normal Subjects: the Sleep Heart Health Study 2009Usual sleep duration and cognitive function in older adults in Spain 2010Sleep Health in U.S. Hispanic Population

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