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Job satisfaction among employees is an indicator of organisational effectiveness, and is influenced by organisational and dispositional factors. The objective of this research was to determine the relationship between personality dimensions and job satisfaction in a pharmaceutical organisation. A cross-sectional design was used to address the research objective. The sample consisted of 159 employees in a pharmaceutical organisation. The Minnesota Satisfaction Questionnaire (MSQ) and the NEO Personality Inventory Revised (NEO-PI-R) were used as measuring instruments. The results showed that job satisfaction has a negative relationship with Anger-hostility (a component of Neuroticism), while it has a positive relationship with positive emotions (a facet of Extraversion), Confidence, Altruism, and Compliance (facets of Agreeableness), as well as facets of Conscientiousness. Personality dimensions explain 28% of the variance of job satisfaction.
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