Social support, social integration, and inflammatory cytokines: A meta-analysis.

Bert N. Uchino · Ryan Trettevik · Robert G. Kent de Grey · Sierra B. Cronan · Jasara N. Hogan · Brian Baucom

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Health disparities and outcomes Stress Responses and Cortisol Tryptophan and brain disorders

Abstract

OBJECTIVE: Social support and social integration have been linked to lower rates of morbidity and mortality. However, the biological mechanisms responsible for such links need greater attention to advance theory and unique intervention opportunities. The main aim of this article was to conduct a meta-analytic review of the association between social support-social integration and inflammatory cytokines (e.g., interleukin-6, C-reactive protein) and test several proposed moderators from prior qualitative reviews. METHOD: . The review identified 41 studies with a total of 73,037 participants. RESULTS: The omnibus meta-analysis showed that social support-social integration were significantly related to lower levels of inflammation (Zr = -.073). These results were not moderated by the operationalization of social relationships or the type of population, cytokine, and design. CONCLUSIONS: These data suggest that inflammation is at least one important biological mechanism linking social support and social integration to the development and course of disease. Future work should continue to build on this review and address next-generation questions regarding antecedent processes, mechanisms, and other potential moderators. (PsycINFO Database Record

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References

2009Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement 1985Stress, social support, and the buffering hypothesis.2010Social Relationships and Mortality Risk: A Meta-analytic Review 1988Social Relationships and Health 2004Social Relationships and Health.1994Meta-Analytic Procedures for Social Research.2011Mechanisms Linking Social Ties and Support to Physical and Mental Health 1998Fixed- and random-effects models in meta-analysis.

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