Global deficits in executive functioning are transdiagnostic mediators between severe childhood neglect and psychopathology in adolescence

Mark Wade · Charles H. Zeanah · Nathan A. Fox · Charles A. Nelson

67 citations0/0 files storedPsychological Medicine

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Child Welfare and Adoption Child and Adolescent Psychosocial and Emotional Development Child Abuse and Trauma

Abstract

BACKGROUND: Children reared in institutions experience profound deprivation that is associated with both heightened levels of psychopathology and deficits in executive functioning (EF). It is unclear whether deficits in EF among institutionally-reared children serve as a vulnerability factor that increases risk for later psychopathology. It is also unclear whether this putative association between EF and psychopathology is transdiagnostic (i.e. cuts across domains of psychopathology), or specific to a given syndrome. Thus, we examined whether global deficits in EF mediate the association between severe childhood neglect and general v. specific psychopathology in adolescence. METHODS: The sample consisted of 188 children from the Bucharest Early Intervention Project, a longitudinal study examining the brain and behavioral development of children reared in Romanian institutions and a comparison group of never-institutionalized children. EF was assessed at age 8, 12, and 16 using a well-validated measure of neuropsychological functioning. Psychopathology was measured as general (P) and specific internalizing (INT) and externalizing (EXT) factors at age 12 and 16. RESULTS: Institutionally-reared children had lower global EF and higher general psychopathology (P) at all ages compared to never-institutionalized children. Longitudinal path analysis revealed that the effect of institutionalization on P at age 16 operated indirectly through poorer EF from ages 8 to 12. No indirect effects involving EF were observed for INT or EXT at age 16. CONCLUSIONS: We conclude that stable, global deficits in EF serve as a cognitive endophenotype that increases transdiagnostic vulnerability to psychopathology in adolescence among those who have experienced profound early neglect.

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References

2003Testing Mediational Models With Longitudinal Data: Questions and Tips in the Use of Structural Equation Modeling.2013The p Factor 2010Emotion-Related Self-Regulation and Its Relation to Children's Maladjustment 2018All for One and One for All: Mental Disorders in One Dimension 2012Is there a general factor of prevalent psychopathology during adulthood?2007Neurobehavioral Therapies in the 21st Century: Summary of an Emerging Field and an Extended Example of Cognitive Control Training for Depression 2010Neurodevelopmental Effects of Early Deprivation in Postinstitutionalized Children 2002Assessment of Neuropsychological Function Through Use of the Cambridge Neuropsychological Testing Automated Battery: Performance in 4- to 12-Year-Old Children

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