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We performed a macroscopic and radiological inspection in a set of bones belonging to the fossil mammal assemblage of Zabelê Paleontological Site (Late Pleistocene-Northgrippian), in northeastern Brazil. Radiological analyzes were carried out using conventional X-ray and X-ray microtomography (µCT) equipment. This study revealed four different types of diseases (calcium pyrophosphate deposition disease – CPPD, infection, trauma and tendon avulsion) restricted to the giant ground sloth E. laurillardi (5.36% of MNI) and in an indeterminate mammal species. The apparent restriction to E. laurillardi is related to taphonomic/palaeoecological bias. The data expand the number of occurrences of diseases in xenarthras species.
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