Como interpretar una revisión sistemática con comparaciones múltiples o network metaanálisis

Abstract

sistemática con comparaciones múltiples o network metaanálisisgonzaLo LaBarca 1,2 , Juan P. uriBe 3 , aDnan maJiD 3 , erik FoLch 4 , seBasTián FernanDez-Bussy 5How to interpret systematic reviews with multiple comparisons or network meta-analysis Systematic reviews evaluating multiple interventions can be useful in different clinical situations.However, some concerns arise when more than two interventions are compared and there is a paucity of good quality randomized clinical trials.A novel statistical method based on indirect comparisons, called network meta-analysis (NMA), can be a useful approach to find a clinical answer when multiple interventions are evaluated for the same outcome or comparator.The aim of this review is to describe the main characteristics and provide a user guide for a critical analysis of NMA focusing on its three main domains, namely homogeneity, transitivity and consistency.

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