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Background. The healthcare system in Jordan faced substantial burden during the 2020 COVID‐19 pandemic including disruption of routine childhood vaccination services. Aims. We sought, for the first time, to describe the impact of the 2020 pandemic on vaccination coverage of Jordanian children in Jordan and to identify the key contributing factors. Methods. Nationwide vaccination rates were retrieved from the electronic records at the Ministry of Health (2018–2020) enrolling crude births of 220,057 Jordanian children during 2020. Records of doses administered were compared for each month of 2020 with the baseline of 2018–2019. A cross‐sectional survey (March–August 2021) was also conducted enrolling a convenient sample of adults aged ≥18 who were Jordanian caregivers for vaccine‐eligible children (0–23 months) between 1 January 2020 and the date of the interview. The survey aimed to address caregivers’ adherence to routine vaccination during 2020–2021 and to describe the determinants of the current and future adherence to vaccination where multiple logistic regression model was utilized. Results. The electronic records revealed a significant decline in vaccination coverage during 2020. The greatest decline was observed during the lockdown period from 21 March 2020 to 21 April 2020 (32.4%–46.8%) followed by the decline observed by the entry of the first wave during September‐October 2020 (18.4%–22.8%). A drop of 14–16% was observed for the vaccines recommended under the age of 12 months and of 6–7% for those recommended in 1‐2‐year‐old children. The yearly coverage rates for measles‐1 (at 9 months), 2 (at 12 months as part of measles‐mumps‐rubella (MMR) vaccine), and 3 (at 18 months as part of MMR) were 76%, 90%, and 87%, respectively, and for hexavalent‐1, 2, and 3 were 78%, 78%, and 77%, respectively. The results of the survey revealed that the main reason for vaccination delay for at least 1 month from the recommended administration time was the lockdown, followed by child illness and smart lockdowns (regional lockdown/health center closure). Vaccination delay was less likely to be observed in children aged ≥12 months (P value < 0.001; OR: 0.18; CI: 0.11–0.29) or children with chronic diseases (P value < 0.05; OR: 0.5; CI: 0.33–0.88). Conclusion. The current study demonstrates a decline in vaccination coverage of Jordanian children during the 2020 COVID‐19 pandemic. It is important to formulate future strategies to promote catch‐up vaccination and to avoid future backsliding of vaccination rates during further waves of the COVID‐19 pandemic or other pandemics. These include improving health services, allaying caregivers’ concerns about contracting COVID‐19, and arranging vaccination campaigns outside health centers.
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