Results of Viral Marker Screening of Unpaid Blood Donations and Probability of Window Period Donations in 1997

Konstanze Müller-Breitkreutz

46 citations0/0 files storedVox Sanguinis

No readable copy stored yet — this record is metadata only.

No open-access location is known for this record yet.

Literature note Cite in a project Citation map

Blood donation and transfusion practices HIV/AIDS Research and Interventions Blood transfusion and management

Abstract

Abstract Background and Objectives: To monitor the safety of the blood supply and evaluate the potential benefits of additional measures, the likelihood of virus transmission must be assessed. The European Plasma Fractionation Association and its member organisations have therefore developed a surveillance system to monitor infection markers among unpaid blood and plasma donors. We report and analyse the results of this surveillance for 1997. Materials and Methods: Data from the screening of unpaid donations for anti‐HIV, anti‐HCV and HBsAg during 1997 were collected retrospectively by EPFA member organisations. We identified serocon verters and estimate the probability of window period donations. Results: Data included screening results from 11 million unpaid donations in Europe, the USA and Australia. Prevalence of viral markers varied, with marker rates from repeat donations in Europe and Australia being significantly lower than in the USA. For first time donations, in contrast, prevalence of HBsAg in the USA was within the ranges of those measured in Europe and Australia. Screening data of about 5 million European and 0.5 million Australian repeat donations were used to identify seroconverters. From the seroconverters that were detected among the European organisations, we estimated that 1 in every 2,323,778 repeat donations (range: 707,090–20,922,520) was made during the window period of anti‐HIV screening. One in 620,754 (201,216–2,316,805) and 1 in 398,499 (155,209 to >1,088,511) repeat donations were made during the anti‐HCV or HBsAg window period, respectively. Probabilities of window period donations in Australia were within the ranges of those measured in Europe. Conclusions: The collated surveillance data of 1997 illustrate the high degree of safety in blood and plasma products from unpaid donors.

Paper brief

Loading…

Cite this work

Citation unavailable for this work.

BibTeX RIS CSL-JSON

No public copy is stored for this record, so only the metadata is cited.

Citations in this library

Citation map →

Stored only when both papers are in the corpus — 46 citations exist upstream.

References

1996The Risk of Transfusion-Transmitted Viral Infections 1995Estimated Risk of Transmission of the Human Immunodeficiency Virus by Screened Blood in the United States 1999Feasibility and efficacy of routine PCR screening of blood donations for hepatitis C virus, hepatitis B virus, and HIV-1 in a blood-bank setting 1998False-Positive HIV-1 Test Results in a Low-Risk Screening Setting of Voluntary Blood Donation 1995Safety of the Blood Supply 1999Transfusion‐transmitted diseases: risks, prevention and perspectives

Cited by

2002Residual risk of transfusion‐transmitted HCV and HIV infections by antibody‐screened blood in Italy 2007Payment for whole blood donations in Lithuania: the risk for infectious disease markers 2001Variant Creutzfeldt‐Jakob disease in Australian blood donors: estimation of risk and the impact of deferral strategies 2000Getting People to Give Blood 2004Infectious Risks Associated with the Transfusion of Blood Components and Pathogen Inactivation in Japan 2003Nucleic acid technology screening of Australian blood donors for hepatitis C and human immunodeficiency virus‐1 RNA: comparison of two high‐throughput testing strategies

Explore the map →

Papers that cite the same references — the relational fallback while embeddings are still backfilling.

Imported from OpenAlex (CC0) — nothing here is generated.