Serial analysis of hematological, biochemical, and immunological parameters alterations in regular healthy voluntary donors during plateletpheresis donation

Rekha Hans · Deepak Pahwa · Jyotdeep Kaur · Biman Saikia · Ratti Ram Sharma · Neelam Marwaha

6 citations0/0 files storedAsian Journal of Transfusion Science

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Blood donation and transfusion practices Platelet Disorders and Treatments Blood transfusion and management

Abstract

Abstract BACKGROUND AND OBJECTIVES: The long-term effect of regular plateletpheresis on donors has not been characterized. Hence, we planned to study the long-term alterations in hematological, biochemical, and immunological parameters in regular repeat platelet apheresis donors. MATERIALS AND METHODS: Thirty-three healthy voluntary regular repeat apheresis donors presenting for platelet donation, fulfilling the requisite donor selection criteria, underwent sequential analysis of the hematological, biochemical, and immunological parameters over 1 year. RESULTS: A total of 33 regular repeat donors were enrolled in the study; out of these, 22 could be followed up to 3 months, 12 up to 6 months, and 10 donors up to 12 months for their hematological, biochemical, and immunological parameters. Overall, there was no significant change in hematological profile except a rise in platelet count at 3 months ( P = 0.023) with no significant difference at 6 and 12 months from the baseline. In addition, serum thrombopoietin levels at 3 months ( P = 0.010) and serum erythropoietin at 6 months ( P = 0.01) were significantly higher than baseline. Mean platelet volume was significantly higher from baseline at 12 months ( P = 0.00). Serum protein, lymphocyte subpopulation, and serum ferritin did not show any significant change from baseline over 12 months of follow-up. However, there was a significant decline ( P = 0.00) in serum calcium and an increase in serum magnesium from baseline ( P = 0.03) at 12 months. INTERPRETATIONS AND CONCLUSIONS: To conclude, apheresis platelet donation is a safe procedure. However, a complete hematological, biochemical, immunological profile and bone marrow density at regular intervals (3–6 months) are recommended to ensure the safety of regular repeat plateletpheresis donors.

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2001Sustained decreases in platelet count associated with multiple, regular plateletpheresis donations 1981The safety of weekly plateletpheresis: effect on the donors' lymphocyte population 2009Apheresis affects bone and mineral metabolism 2009Study of iron stores in regular plateletpheresis donors 1986Effects of frequent and sustained plateletapheresis on peripheral blood mononuclear cell populations and lymphocyte functions of normal volunteer donors 2007Frequent plateletpheresis does not clinically significantly decrease platelet counts in donors 2014Changes in pre- and post-donation haematological parameters in plateletpheresis donors 1997Effect of long-term platelet donation on lymphocyte subsets and plasma protein concentrations

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