Articlebronze2026

Serum Cingulin and Interleukin‐6 Levels in Children With Specific Learning Disorder

1 citations0/0 files storedInternational Journal of Developmental Neuroscience

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Developmental and Educational Neuropsychology Reading and Literacy Development Neuroinflammation and Neurodegeneration Mechanisms

Abstract

BACKGROUND: This study examined cingulin and interleukin-6 (IL-6) levels in children with specific learning disorder (SLD) to explore their association with inflammation and tight junction-related barrier biological processes in the context of the disorder. METHODS: The research compared 40 children with SLD and 41 healthy peers using a cross-sectional, case-controlled design. Serum cingulin and IL-6 levels were measured using the ELISA method. The Mathematics, Reading and Writing Assessment Scale (MOYA) teacher and parent forms were applied to evaluate disease severity in the SLD group. RESULTS: Both cingulin and IL-6 levels were significantly higher in the SLD group than in the controls (p = 0.005 and p = 0.009, respectively). These differences maintained their significance during covariance analysis. These findings indicate a significant group-related difference in cingulin and IL-6 levels, and that this was independent of age, gender and body mass index. A positive correlation was determined between cingulin and IL-6 in the SLD group (r = 0.472, p = 0.020). In the context of logistic regression analysis, cingulin demonstrated an independent association with the presence of SLD (OR = 1.006, p = 0.041), while IL-6 did not. An AUC value of 0.679 was calculated for cingulin at receiver operating characteristic analysis (p = 0.003). CONCLUSION: Elevated serum cingulin and IL-6 levels in children with SLD may reflect inflammatory activity and barrier-related biological processes associated with the disorder. These findings should be interpreted as preliminary and require confirmation in larger, longitudinal studies incorporating direct assessments of barrier function.

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References

2013Diagnostic and Statistical Manual of Mental Disorders 2010Association between Plasma IL-6 Response to Acute Stress and Early-Life Adversity in Healthy Adults 2019Understanding, educating, and supporting children with specific learning disabilities: 50 years of science and practice.2019Reliability and Validity of the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version, DSM-5 November 2016-Turkish Adaptation (K-SADS-PL-DSM-5-T)2022Prevalence of Developmental Dyslexia in Primary School Children: A Systematic Review and Meta-Analysis 2022Prevalence of Specific Learning Disorders (SLD) Among Children in India: A Systematic Review and Meta-Analysis 2022Elevated Monocyte Levels Maybe a Common Peripheral Inflammatory Marker in Specific Learning Disorders and Attention Deficit/Hyperactivity Disorder 2022The role of inflammation in children with specific learning disorders

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