Article1995

Sertraline for social phobia: a double-blind, placebo-controlled crossover study

David J. Katzelnick · Kenneth A. Kobak · John H. Greist · James W. Jefferson · Julia M. Mantle

239 citations0/0 files storedAmerican Journal of Psychiatry

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Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Schizophrenia research and treatment Treatment of Major Depression

Abstract

OBJECTIVE: The authors examined the efficacy of sertraline in the treatment of social phobia. METHOD: In a double-blind crossover study, 12 outpatients were randomly assigned to 10 weeks of sertraline (50-200 mg/day, flexible dosing) and 10 weeks of placebo. RESULTS: A statistically significant improvement in scores on the Liebowitz Social Anxiety Scale was found with sertraline but not with placebo. There was no significant difference between scores obtained with computer- and clinician-administered versions of the Liebowitz Social Anxiety Scale, and the majority of patients preferred to be interviewed by the computer. CONCLUSIONS: Sertraline seems a safe and effective treatment for social phobia, and computer administration may be a preferable mode of assessment with socially phobic patients.

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References

1979A New Depression Scale Designed to be Sensitive to Change 1994Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States 2015Social Phobia 1979Brief standard self-rating for phobic patients 1985Social Phobia 1992Pharmacotherapy of Social Phobia 1988Return of symptoms after discontinuation of clomipramine in patients with obsessive-compulsive disorder 1994Psychopharmacological treatment of social phobia; a double blind placebo controlled study with fluvoxamine

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1997A Computer-Administered Telephone Interview to Identify Mental Disorders 2004Efficacy of the Novel Anxiolytic Pregabalin in Social Anxiety Disorder 2001Sertraline Treatment of Generalized Social Phobia: A 20-Week, Double-Blind, Placebo-Controlled Study 2001Social Anxiety Disorder in Childhood and Adolescence: Current Status and Future Directions 1998Clinical utility of the selective serotonin reuptake inhibitors in the spectrum of anxiety

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