Long-Term Follow-Up of Donors Cytapheresed More Than 50 Times

Joanna Mary Heal · Paul K. Horan · Jacob Nusbacher

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Blood donation and transfusion practices Hematopoietic Stem Cell Transplantation Blood transfusion and management

Abstract

11 volunteers who had donated white blood cells or platelets more than 50 times over a 5- to 9-year period were studied to determine whether any adverse consequences of many cytaphereses could be detected. Among the donors no significant differences were found in 18 hematological and biochemical parameters when compared to a group of age- and sex-matched nondonor controls. Despite extensive cumulative lymphocyte losses sustained by these donors, the ratio of T, B, helper and suppressor cells has been maintained within the normal range. No detrimental effects of multiple cytapheresis on the donors' health has been demonstrated to date.

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References

1971Leukocyte and Platelet Collection from Normal Donors with the Continuous Flow Blood Cell Separator 1981The safety of weekly plateletpheresis: effect on the donors' lymphocyte population 1980Frequent Multiunit Plateletpheresis from Single Donors: Effects on Donors' Blood and the Platelet Yield

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1984Apheresis donor safety ‐ changes in humoral and cellular immunity 1986Effects of frequent and sustained plateletapheresis on peripheral blood mononuclear cell populations and lymphocyte functions of normal volunteer donors 1992Repeat Plateletpheresis: The Effects on the Donor and the Yield 1991In vitro study of immunologic changes in long‐term cytapheresis donors 2005Mononuclear cell variability and recruitment in non‐cytokine‐stimulated donors after serial 10‐liter leukapheresis procedures 198415 Health Risks to Cytapheresis Donors 1985Peripheral blood lymphocyte numbers, lymphocyte proliferative responses in vitro, and serum immunoglobulins in regular hemapheresis donors 1997Effect of long-term platelet donation on lymphocyte subsets and plasma protein concentrations

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