Article1992

Response to hyperventilation and inhalation of 5.5% carbon dioxide-enriched air across the DSM-III--R anxiety disorders.

Ronald M. Rapee · Timothy A. Brown · Martin M. Antony · David Harrison Barlow

287 citations0/0 files storedJournal of Abnormal Psychology

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Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes Psychosomatic Disorders and Their Treatments Neuroscience of respiration and sleep

Abstract

Anxiety disorder patients (n = 198; under criteria of the Diagnostic and Statistical Manual of Mental Disorders; rev. 3rd ed.; American Psychiatric Association, 1987) and nonanxious control subjects (n = 25) underwent challenges of 90 s of voluntary hyperventilation and 15 min of 5.5% carbon dioxide in air. Panic disorder subjects showed a greater subjective response to both challenges than did subjects with other anxiety disorders, who in turn responded more than did control subjects. Furthermore, subjects with panic disorder as an additional diagnosis tended to report more subjective response than did anxiety disorder subjects without panic disorder. The best prechallenge predictor of response to each procedure was a measure of fear of physical symptoms. The findings support previous results that have pointed to a greater fear or anxiety-inducing effect of these challenge procedures in panic disorder patients, as compared with other subjects.

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References

1959THE ASSESSMENT OF ANXIETY STATES BY RATING 1986Anxiety sensitivity, anxiety frequency and the prediction of fearfulness 1990Comorbidity of mood and anxiety disorders 1967A paradox in the interpretation of group comparisons.1993Reliability of DSM-III-R Anxiety Disorder Categories 1989The Influence of an Illusion of Control on Panic Attacks Induced via Inhalation of 5.5% Carbon Dioxide-Enriched Air 1984Response to hyperventilation in a group of patients with panic disorder 1988Ventilatory Physiology of Patients With Panic Disorder

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