Ten steps towards improving prognosis research

Harry Hemingway · Richard D Riley · Douglas G. Altman

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Meta-analysis and systematic reviews Statistical Methods in Epidemiology Delphi Technique in Research

Abstract

Prognosis research should be a basic science in translational medicine, but methodological problems mean systematic reviews are unable to reach firm conclusions. Harry Hemingway and colleagues recommend action to improve the quality

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References

2005Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK)2006Evaluation of the Quality of Prognosis Studies in Systematic Reviews 2003How important are comprehensive literature searches and the assessment of trial quality in systematic reviews? Empirical study 2009Systematic reviews of low back pain prognosis had variable methods and results—guidance for future prognosis reviews 2007Almost all articles on cancer prognostic markers report statistically significant results 2005Selective Reporting Biases in Cancer Prognostic Factor Studies 2003Reporting of prognostic markers: current problems and development of guidelines for evidence-based practice in the future 2009Prognostic markers in cancer: the evolution of evidence from single studies to meta-analysis, and beyond

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2010Evaluating the Quality of Research into a Single Prognostic Biomarker: A Systematic Review and Meta-analysis of 83 Studies of C-Reactive Protein in Stable Coronary Artery Disease 2014Improving the Transparency of Prognosis Research: The Role of Reporting, Data Sharing, Registration, and Protocols 2015Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis ( TRIPOD ): the TRIPOD statement

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