STrengthening the Reporting of OBservational studies in Epidemiology – Molecular Epidemiology (STROBE-ME): An Extension of the STROBE Statement

Abstract

Advances in laboratory techniques have led to the increasing use of biomarkers in epidemiological studies, but the quality of reporting of such studies varies. The STROBE (STrengthening Reporting of Observational studies in Epidemiology) initiative, established in 2004, provides guidance on reporting observational epidemiology studies. Here, the STROBE-ME (Strengthening the Reporting of OBservational studies in Epidemiology – Molecular Epidemiology) initiative builds on STROBE and provides additional guidance on reporting biomarker studies. Specific additions relate to the collection, handling and storage of biological samples; laboratory methods, validity and reliability of biomarkers; specificities of study design; and ethical considerations. A checklist to help authors in reporting biomarker studies is published as supporting information.

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