Predictors of hemoglobin recovery or deferral in blood donors with an initial successful donation

Brian Custer · Marjorie D. Bravo · Roberta L. Bruhn · Kevin J. Land · Peter Tomasulo · Hany T. Kamel

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Blood donation and transfusion practices Iron Metabolism and Disorders Blood transfusion and management

Abstract

BACKGROUND: Donation eligibility is based on hemoglobin (Hb) level among other factors. This study assesses factors that influence Hb levels among first-time (FT) donors returning for a second donation. STUDY DESIGN AND METHODS: Allogeneic FT donors who successfully donated a red blood cell (RBC)-containing donation on their index presentation and returned to donate at least once more between August 1, 2009, and July 31, 2012, were included. Interdonation intervals and delta Hb (subsequent donation - index donation value) were calculated. Multivariable logistic regression and survival analysis methods were used to determine factors associated with 1) Hb recovery to preindex donation value or 2) deferral at the second presentation. RESULTS: During the study, 135,040 FT donors returned to donate. Overall, 44% of donors returned with a Hb level at or above their index value (defined as recovery for this study), 48.1% for males and 39.9% for females. Logistic regression revealed that the factor most strongly associated with Hb recovery was index Hb, with lower Hb having much higher odds of recovery. Shorter interdonation intervals were associated with decreased likelihood of recovery. Certain demographic characteristics were also associated with higher odds of recovery. Factors associated with deferral were similar to the factors associated with recovery, except for donor sex. CONCLUSIONS: As early as the second blood donation, allogeneic donors can be differentiated into two subpopulations: those who recover to index Hb levels and those who do not. Current data routinely collected by US blood centers cannot reliably distinguish between the two groups.

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References

1977Standards for blood banks and transfusion services.2006Iron depletion by whole‐blood donation harms menstruating females: The current whole‐blood‐collection paradigm needs to be changed 2010Demographic correlates of low hemoglobin deferral among prospective whole blood donors 2010The impact of temporary deferral due to low hemoglobin: future return, time to return, and frequency of subsequent donation 2008Recovery of hemoglobin mass after blood donation 2011Demographics of successful, unsuccessful and deferral visits at six blood centers over a 4‐year period 2011Reliability of capillary hemoglobin screening under routine conditions 1942RATE OF HEMOGLOBIN REGENERATION IN BLOOD DONORS

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2015Database research in transfusion medicine: The power of large numbers 2016Season and time of day affect capillary blood hemoglobin level and low hemoglobin deferral in blood donors: analysis in a national blood bank 2019Changes in minimum hemoglobin and interdonation interval: impact on donor hemoglobin and donation frequency 2017Retrospective analysis of capillary hemoglobin recovery in nearly 1 200 000 blood donor returns

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