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Abstract The Global South faces significant healthcare challenges, making the achievement of Sustainable Development Goal 3 (SDG 3): Good Health and Wellbeing difficult by 2030. This study aims to identify the key challenges associated with each SDG 3 target. Major barriers include poor healthcare infrastructure, financial constraints, workforce shortages, high out-of-pocket healthcare expenses and the lack of universal health coverage. To address these issues, the study explores the feasibility of Micro-Healthcare Entrepreneurship (MHE) as an innovative and sustainable model for improving healthcare accessibility and affordability. MHE integrates local entrepreneurship, digital health technologies, mentorship and social business funding to create an affordable and easily accessible, community-driven preventive healthcare solution. The study identifies critical implementation challenges, including financial sustainability, regulatory barriers, limited ICT infrastructure, workforce shortages and cultural resistance. The findings suggest that digital health innovations, public–private partnerships and social business models can significantly enhance healthcare service delivery in resource-limited settings. Comparing MHE with existing healthcare delivery models, this research highlights its potential to bridge healthcare gaps by reducing dependency on centralised hospitals and limited resources. By leveraging technology, entrepreneurship and social impact, MHE can become one of the sustainable solutions for accessible, affordable and quality healthcare service delivery approach in Global South countries, contributing to the achievement of SDG 3 and beyond.
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